Searching for the Cosmic Dawn with the Hyperfine Structure Transition of Hydrogen

The 21 cm hyperfine structure transition of neutral hydrogen promises to open a window into the first billion years of the Universe (z &#62; 6). With the exception of rare lines of sight towards exceptionally distant and luminous galaxies, this period of the universe's history remains largely unexplored. During this time the 21 cm transition is expected to be detectable as a 10--100 mK perturbation in the thermal Cosmic Microwave Background (CMB) spectrum. Due to the large field of view of low frequency radio telescopes (typically composed of dipole antennas) and the fact that the line of sight distance can be inferred from the measured frequency of the transition, the ultimate goal of 21 cm cosmology is to produce three dimensional tomographic maps of the 21 cm brightness temperature. In this way, the formation of the first stars and galaxies will be revealed through their influence on the neutral gas around them. This thesis saw the construction of the Owens Valley Radio Observatory Long Wavelength Array (OVRO-LWA), a new low frequency (27--85 MHz) radio telescope located near Bishop, California. Composed of 288 crossed-dipole antennas, the OVRO-LWA is capable of imaging the entire visible hemisphere in a single 13 s snapshot image with 8 arcmin angular resolution. The primary challenges faced by efforts to detect the highly redshifted 21 cm transition are seeing past the blinding glow of foreground radio emission that is five orders of magnitude brighter than the cosmological emission, and calibrating the instrument to a level where it's possible to make the separation between foreground emission and the 21 cm signal. In this thesis I will present foundational work using the OVRO-LWA to place upper limits on spatial fluctuations of the 21 cm transition during the Cosmic Dawn---the period of first star formation. In this thesis I present the highest angular resolution maps of the full sky below 100 MHz, and generated with a new widefield imaging technique that is specialized for drift scanning interferometers. These sky maps are a 10-fold improvement in angular resolution over existing maps at comparable frequencies, and are publicly available now for use in modeling and subtracting the contamination of foreground emission in 21 cm experiments. Using a 28 hr integration with the OVRO-LWA, I place to-date the most constraining upper limits on the amplitude of the 21 cm spatial power spectrum at the Cosmic Dawn, and the first limits at z &#62; 18. Although the current constraints Δ212 ≲ (104mK)2 do not meaningfully restrict the parameter space of models of early star formation, they do inform the design and calibrations necessary for future measurements to push towards a detection of the high-redshift 21 cm transition. In making this measurement I demonstrate the application of a new foreground filter that accounts for the full covariance of the foreground emission, and provide an updated measurement of the foreground angular covariance. Finally, I interpret the limiting factors in this measurement and determine the instrumental calibration and characterization requirements the OVRO-LWA will need to achieve in order to make a detection of the 21 cm power spectrum of the Cosmic Dawn.</p

HelioSwarm: A Multipoint, Multiscale Mission to Characterize Turbulence

HelioSwarm (HS) is a NASA Medium-Class Explorer mission of the Heliophysics Division designed to explore the dynamic three-dimensional mechanisms controlling the physics of plasma turbulence, a ubiquitous process occurring in the heliosphere and in plasmas throughout the universe. This will be accomplished by making simultaneous measurements at nine spacecraft with separations spanning magnetohydrodynamic and sub-ion spatial scales in a variety of near-Earth plasmas. In this paper, we describe the scientific background for the HS investigation, the mission goals and objectives, the observatory reference trajectory and instrumentation implementation before the start of Phase B. Through multipoint, multiscale measurements, HS promises to reveal how energy is transferred across scales and boundaries in plasmas throughout the universe

High Throughput Screening for Small Molecule Enhancers of the Interferon Signaling Pathway to Drive Next-Generation Antiviral Drug Discovery

Most of current strategies for antiviral therapeutics target the virus specifically and directly, but an alternative approach to drug discovery might be to enhance the immune response to a broad range of viruses. Based on clinical observation in humans and successful genetic strategies in experimental models, we reasoned that an improved interferon (IFN) signaling system might better protect against viral infection. Here we aimed to identify small molecular weight compounds that might mimic this beneficial effect and improve antiviral defense. Accordingly, we developed a cell-based high-throughput screening (HTS) assay to identify small molecules that enhance the IFN signaling pathway components. The assay is based on a phenotypic screen for increased IFN-stimulated response element (ISRE) activity in a fully automated and robust format (Z′>0.7). Application of this assay system to a library of 2240 compounds (including 2160 already approved or approvable drugs) led to the identification of 64 compounds with significant ISRE activity. From these, we chose the anthracycline antibiotic, idarubicin, for further validation and mechanism based on activity in the sub-µM range. We found that idarubicin action to increase ISRE activity was manifest by other members of this drug class and was independent of cytotoxic or topoisomerase inhibitory effects as well as endogenous IFN signaling or production. We also observed that this compound conferred a consequent increase in IFN-stimulated gene (ISG) expression and a significant antiviral effect using a similar dose-range in a cell-culture system inoculated with encephalomyocarditis virus (EMCV). The antiviral effect was also found at compound concentrations below the ones observed for cytotoxicity. Taken together, our results provide proof of concept for using activators of components of the IFN signaling pathway to improve IFN efficacy and antiviral immune defense as well as a validated HTS approach to identify small molecules that might achieve this therapeutic benefit

Thomas P. Branson (1953 2006)

© Springer. Part of Springer Science+Business MediaAlice Chang, Mike Eastwood, Rod Gover, Palle Jorgensen, Gestur Ólafsson, Bent Ørsted, Paul Yang, Lawrence Peterson, Oleg Svidersky, William Ugalde and Doojin Hon

Disentangling the Spatiotemporal Structure of Turbulence Using Multi-Spacecraft Data

This white paper prepared for the 2024 Decadal Survey for Solar and Space Physics concerns the importance of research related to multi-spacecraft missions to address fundamental questions concerning plasma turbulence. In this white paper, some of the important questions facing the turbulence community that can only be addressed by funding research related to multipoint measurements are presented